To change the active modifier in the middle of a drawing command, use the Function Keys. This is useful if, for example, you want to begin a line by snapping it to a gridpoint, but end it by snapping it to the endpoint of another line which might not be on the grid.
The Function Keys toggle modifiers as follows:
F5 - Snap to Grid
F6 - Snap to Intersection
F7 - Snap to Object
F8 - Snap to Rotation
F9 - Orthogonal Lock